In this film, Wouter de Graaff, VP of R&D at QPharma, elaborates on the design of intravaginal drug-releasing rings (IVRs). Besides providing background on IVR development, which includes polymer selection and drug release kinetics, the topic of simultaneous drug release is covered.

Hot Melt Extrusion (HME) is one of several solubilization techniques used by the pharmaceutical industry to enhance the solubility of APIs. HME is a desirable strategy because it is a controllable process that promotes miscibility of the API in a polymer matrix.

QPharmas' facility in Malmö, Sweden, features state-of-the-art suites dedicated to GMP and non-GMP development of polymer based delivery systems. Our Malmö site utilizes advanced polymer extrusion technologies for the production of implants, drug eluting intrauterine devices and intra-vaginal rings. The air circulation in the suites is single pass and state-of-the-art engineering controls are in-place.

QPharmas' US site in Putnam, CT, features two fully commissioned and qualified High Potent API handling suites: One for development, one for GMP manufacturing. Designed with twin and single screw extrusion in mind, these suites bring flexibility, safety, and efficiency to your drug product development journey. See what makes Putnam a uniquely capable partner for your most challenging formulations.