Poor solubility remains one of the biggest obstacles in pharmaceutical development. Hot Melt Extrusion (HME) enables innovative formulations that improve bioavailability while opening new possibilities for complex therapies. QPharma combines advanced Hot Melt Extrusion technology with extensive formulation expertise to help customers overcome demanding development challenges.

The Challenge

Many promising drug candidates struggle with poor solubility, limiting their therapeutic potential and commercial viability. Developing effective formulations requires specialized expertise, advanced equipment and a deep understanding of material science.

Our solution

We work closely with customers to develop optimized formulations using Hot Melt Extrusion technology, helping improve solubility, stability and manufacturing efficiency. Our integrated approach combines formulation development, process optimization and manufacturing under one roof.

Key benefits

• Improved bioavailability

• Advanced formulation expertise

• Integrated process development

• Commercial manufacturing capabilities

Amorphous solid dispersion

Approximately 75% of new chemical entities (NCEs) and a significant portion of marketed products are poorly water-soluble. In an amorphous solid dispersion (ASD), the drug is dispersed in a non-crystalline state with the polymer carrier. This can increase the apparent solubility and dissolution rate compared to the crystalline drug. The polymer also helps keep the drug in amorphous form during storage and maintains drug supersaturation after dissolution.

HME is a solvent-free and continuous manufacturing method established for preparing ASDs. We are not only experts in preparing ASDs of highly potent, difficult molecules, but also in reducing the processing temperatures to overcome challenges of HME and form stable ASDs. The extrudates can be milled and finished as tablets, capsules, or other oral solid dosage forms. At QPharma, we combine formulation development, process optimization, and manufacturing to develop ASDs suited to your molecule.

Let’s start the conversation

How can we support you in your next project?